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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
15.15
Human Site:
Y204
Identified Species:
27.78
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
Y204
S
A
S
C
R
H
E
Y
P
L
S
W
M
K
E
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
K159
E
D
C
Q
S
L
V
K
P
D
I
V
F
F
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
D187
C
H
S
V
V
K
P
D
I
V
F
F
G
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
Y204
N
T
S
C
R
K
E
Y
T
M
G
W
M
K
E
Rat
Rattus norvegicus
Q5RJQ4
350
39301
V190
K
C
E
K
C
Q
N
V
V
K
P
D
I
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
Y218
R
S
S
C
R
H
Q
Y
D
L
S
W
V
K
E
Frog
Xenopus laevis
NP_001088636
413
45548
Y232
G
A
F
C
G
A
E
Y
S
L
S
W
M
K
E
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
Y202
S
F
L
C
R
K
E
Y
S
M
D
W
M
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
G195
P
K
C
Q
K
C
Q
G
V
V
K
P
D
I
V
Honey Bee
Apis mellifera
XP_393038
355
40940
R195
H
G
T
F
H
T
G
R
C
L
K
C
R
A
P
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
Y270
C
T
R
C
G
Q
K
Y
D
G
N
E
I
R
E
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
E201
N
C
N
E
M
Y
T
E
E
S
M
R
E
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
L197
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
6.6
N.A.
6.6
N.A.
60
0
N.A.
N.A.
66.6
66.6
53.3
N.A.
0
6.6
20
6.6
P-Site Similarity:
100
6.6
N.A.
26.6
N.A.
73.3
6.6
N.A.
N.A.
86.6
66.6
60
N.A.
20
13.3
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
8
0
0
0
0
0
0
0
8
0
% A
% Cys:
16
16
16
47
8
8
0
0
8
0
0
8
0
0
0
% C
% Asp:
8
8
0
0
0
0
0
8
16
16
8
8
8
0
0
% D
% Glu:
8
0
8
8
8
0
31
8
8
0
0
16
8
8
39
% E
% Phe:
0
8
16
8
0
0
0
0
0
0
8
8
8
8
8
% F
% Gly:
8
8
0
0
16
0
8
8
0
8
8
0
8
0
8
% G
% His:
8
8
0
0
8
16
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
8
0
16
8
8
% I
% Lys:
8
8
0
8
8
24
8
8
0
8
16
0
0
47
0
% K
% Leu:
0
0
8
0
0
8
0
8
0
31
0
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
16
8
0
31
0
0
% M
% Asn:
16
0
8
0
0
0
8
0
8
0
8
0
0
0
16
% N
% Pro:
8
0
0
0
0
0
8
0
16
0
8
8
0
0
8
% P
% Gln:
0
0
0
16
0
16
16
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
8
0
31
0
0
8
0
0
0
8
8
8
8
% R
% Ser:
16
16
31
8
8
0
0
0
16
8
31
0
0
0
0
% S
% Thr:
0
16
8
0
0
16
8
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
8
8
0
8
8
16
16
0
8
8
8
8
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
39
8
0
0
% W
% Tyr:
0
0
0
0
0
8
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _